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KANNER I: Early infantile autism J Pediatr 25:211, 1944 KEMPERMANN G: Why new neurons Possible functions for adult hippocampal neurogenesis J Neurosci 22:635, 2002 KINSBOURNE M: Developmental Gerstmann s syndrome: A disorder of sequencing Pediatr Clin North Am 15:771, 1968 KINSBOURNE M: Disorders of mental development, in Menkes JH (ed): Textbook of Child Neurology, 5th ed Baltimore, Williams & Wilkins, 1995, pp 924 964 KINSEY A, POMEROY W, MARTIN C, GEBHARD P: Sexual Behavior in the Human Female Philadelphia, Saunders, 1948 LANDAU WM, KLEFFNER FR: Syndrome of acquired aphasia with convulsive disorder in children Neurology 7:523, 1957 LENNEBERG EH: Biological Foundations of Language New York, Wiley, 1967 LEONARD CM, VOELLER KKS, LOMBARDINO LJ, et al: Anomalous cerebral structure in dyslexia revealed with magnetic resonance imaging Arch Neurol 50:461, 1993 LEVAY S: A difference in hypothalamic structure between heterosexual and homosexual men Science 253:1034, 1991 LEVAY S, HAMER DH: Evidence for a biological in uence in male homosexuality Sci Am 270:44, 1994 LEWIS EO: Types of mental differences and their social signi cance J Ment Sci 79:298, 1933 LIVINGSTONE MS, ROSEN GD, DRISLANE FW, GALABURDA AM: Physiological and anatomical evidence for a magnocellular defect in developmental dyslexia Proc Natl Acad Sci USA 88:7943, 1991 LOWREY GH: Growth and Development of Children, 8th ed Chicago, Year Book, 1986 MACKINTOSH NJ: IQ and Human Intelligence Oxford, Oxford University Press, 1998 MINIFIE FD, LLOYD LL: Communicative and Cognitive Abilities Early Behavioral Assessment Baltimore, University Park Press, 1978 MOSER HW, RAMEY CT, LEONARD CO: Mental retardation, in Emery AE, Rimoin DL (eds): Principles and Practice of Medical Genetics Edinburgh, Churchill Livingstone, 1984, pp 352 366 ORTON ST: Reading, Writing and Speech Problems in Children New York, Norton, 1937 OZERETZKII NI: Technique of investigating motor function, in Gurevich M, Ozeretzkii NI (eds): Psychomotor Function Moscow, 1930 Quoted by Luria AR: Higher Cortical Functions in Man New York, Basic Books, 1966 PACKMAN A, ONSLOW M: Searching for the cause of stuttering Lancet 360:655, 2002 PAULESU E, DEMONENT J-F, FAZIA F, et al: Dyslexia; cultural diversity and biological unity Science 291:2165, 2001 PIAGET J: The Psychology of Intelligence London, Routledge & Kegan Paul, 1950 PRECHTL HFR: Prognostic value of neurological signs in the newborn Proc R Soc Med 58:3, 1965 PRECHTL HFR, BEINTEMA D: The Neurological Examination of the Full Term Newborn Infant Little Club Clinics in Developmental Medicine, no 12 London, Heinemann, 1964 PRECHTL HFR, STEMMER CJ: The choreiform syndrome in children Dev Med Child Neurol 4:119, 1962 PURPURA D: Dendritic spine dysgenesis in mental retardation Science 186:1126, 1974 RABINOWICZ T: The differential maturation of the cerebral cortex, in Falkner F, Tanner JM (eds): Human Growth New York, Plenum Press, l986 RAPIN I, ALLEN DA: Developmental language disorders: Nosologic considerations, in Kirk U (ed): Neuropsychology of Language, Reading and Spelling New York, Academic Press, 1983, pp 155 184 Raven s Colored Progressive Matrices New York, Psychological Corporation, 1947 1963 REISSMAN F: The Culturally Deprived Child New York, Harper & Row, 1962 RENPENNING H, GERRARD JW, ZALESKI WA, et al: Familial sex-linked mental retardation Can Med Assoc J 87:924, 1962.

ROSENBERGER PB: Morphological cerebral asymmetries and dyslexia, in Pavlidis GT (ed): Perspectives on Dyslexia Vol 1 New York, Wiley, 1990, pp 93 107 ROSENBERGER PB: Learning disorders, in Berg B (ed): Principles of Child Neurology New York, McGraw-Hill, 1996, pp 335 369 RUMSEY JM, DONOHUE BC, BRADY DR, et al: A magnetic resonance imaging study of planum temporale asymmetry in men with developmental dyslexia Arch Neurol 54:1481, 1997 RUTTER M, GRAHAM P, YULE W: Clinics in Developmental Medicine Nos 35 and 36 A Neuropsychiatric Study in Childhood London, Heinemann, 1970 RUTTER M, MARTIN JAM (eds): Clinics in Developmental Medicine No 43 The Child with Delayed Speech London, Heinemann, 1972, pp 48 51 SANDAK R, FIEZ JA: Stuttering: A view from neuroimaging Lancet 356: 445, 2000 SCARR S, WEBBER RA, CUTTING MA: Personality resemblance among adolescents and their parents in biologically related and adoptive families J Pers Soc Psychol 40:885, 1981 SCHAIN RJ: Neurology of Childhood Learning Disorders, 2nd ed Baltimore, Williams & Wilkins, 1977 SHAYWITZ SE: Dyslexia N Engl J Med 338:307, 1998 SHAYWITZ SE, SHAYWITZ BA, FLETCHER JM, et al: Prevalence of reading disabilities in boys and girls JAMA 264:998, 1990 SIMOS PG, FLETCHER JM, BERGMAN G, et al: Dyslexia-speci c brain deterioration pro le becomes normal following remedial training Neurology 58:1203, 2002

SPEARMAN C: Psychology Down the Ages London, Macmillan, 1937 STAPLES R: Responses of infants to color J Exp Psychol 15:119, 1932 STEIN JF, RICHARDSON AJ, FOWLER MS: Monocular occlusion can improve binocular control and reading in dyslexics Brain 123:164, 2000 SWAAB DF, HOFMAN MA: An enlarged suprachiasmatic nucleus in homosexual men Brain Res 537:141, 1990 THURSTONE LL: The Vectors of the Mind Chicago, University of Chicago Press, 1953 TIROSH E: Fine motor de cit: An etiologically distinct entity Pediatr Neurol 10:213, 1994 TRAVIS LE: Speech Therapy New York, Appleton-Century, 1931 TURNER G, TURNER B, COLLINS E: X-linked mental retardation without physical abnormality: Renpenning s syndrome Dev Med Child Neurol 13:71, 1971 WEISS G, HECHTMAN L, MILROY T, PERLMAN T: Psychiatric status of hyperactives as adults: A controlled prospective 15-year follow-up of 63 hyperactive children J Am Acad Child Adolesc Psychiatry 24:211, 1985 WORSTER-DROUGHT C: Congenital suprabulbar paresis J Laryngol Otol 70:453, 1956 YAKOVLEV PI, LECOURS AR: The myelogenetic cycles of regional maturation of the brain, in Minkowski A (ed): Regional Development of the Brain in Early Life Oxford, Blackwell, 1967, pp 3 70 ZAMETKIN AJ, ERNST M: Problems in the management of attention-de cit hyperactivity disorder N Engl J Med 340:40, 1999 ZAMETKIN AJ, NORDAHL TE, GROSS M, et al: Cerebral glucose metabolism in adults with hyperactivity of childhood onset N Engl J Med 323: 1361, 1990

As indicated in the preceding chapter, standards of growth, development, and maturation provide a frame of reference against which every pathologic process in early life must be viewed It has been less appreciated, however, that at the other end of the life cycle, neurologic de cits must be judged in a similar way, against a background of normal aging changes (senescence) The earliest of these changes begins long before the acknowledged period of senescence and continues throughout the remainder of life Not a few medical scientists and physicians believe that all changes in senescence are but the cumulative effects of injury and disease Most authors use the terms aging and senescence interchangeably, but some draw a ne semantic distinction between the purely passive and chronologic process of aging and the composite of bodily changes that characterize this process (senescence) Biologists have measured many of these changes Estimates of the structural and functional decline that accompanies aging from 30 to 80 years are given in Table 29-1 It appears that all structures and functions share in the aging process Some persons withstand the onslaught of aging far better than others, and this constitutional resistance to the effects of aging seems to be familial It can also be said that such changes are unrelated to Alzheimer disease and other degenerative diseases but that in general the changes of aging reduce the ability of the organism to recover from virtually any illness or trauma

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idle, obstinate, and given to reminiscing and as having tremulous hands, quavering voices, stooped posture, and slow, shuf ing steps In so doing, they have selected some of the most obvious effects of aging on the nervous system The lay observer, as well as the medical one, often speaks glibly of the changes of advanced age as a kind of second childhood Old men are boys again, said Aristophanes This view of old age derives from the few resemblances, super cial at best, of the senile dement and the helpless young child

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