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The oliogopeptides vasopressin and oxytocin are elaborated by cells of the supraoptic and paraventricular nuclei and are transported, via their axons, through the stalk of the pituitary to its posterior lobe, where these substances are stored Together, these elements constitute the neurohypophysis (posterior pituitary), which develops as an evagination of the oor of the third ventricle Some of the vasopressin-containing nerve endings also terminate on cells of origin of the autonomic nervous system and on the capillary plexus of the hypophysial portal circulation, through which they in uence the secretion of CRH and GH The peptide parts of vasopressin and oxytocin, whose chemical nature was determined by duVigneaud, are almost identical, differing from one another by only two amino acids Vasopressin, acting on the kidney tubules, serves as the antidiuretic hormone (ADH) and, complemented by thirst mechanisms, maintains the osmolality of the blood Plasma osmolality modi es vasopressin secretion by acting directly on the supraoptic and paraventricular neurons or on separate osmoreceptors in the hypothalamus The sensitivity of the vasopressin-ADH mechanism is demonstrated by the absence of antidiuretic effect when vasopressin is below 1 pg/mL and by maximal antidiuresis when plasma levels reach 5 pg/mL If serum osmolality falls below 280 mosm/L, the release of ADH is completely inhibited This system is most effective in maintaining homeostasis when serum osmolality is relatively close to the normal range, between 280 and 295 mosm/L Alterations in blood volume and pressure also affect vasopressin release through neural mechanisms that have their origin in baro- and mechanoreceptors of the aortic arch, carotid sinus, and right atrium Afferent signals from these regions are conveyed in the vagus and glossopharyngeal nerves, which synapse in the nucleus of the tractus solitarius; the precise pathways to the hypothalamus have not been delineated, however With severe hypotension, ADH release will continue even if there is a low serum osmolality, ie, pressure predominates over osmolarity as a stimulus Vasopressin secretion is also in uenced by nonosmotic factors Nausea, for example, is a potent stimulus, raising levels of the hormone 100-fold Hypoglycemia has a less profound effect Drugs such as morphine, nicotine, alcohol, and certain chemotherapeutic agents (cyclophosphamide) also cause release of the stored peptide Pain, emotional stress, and exercise have long been thought to cause release of vasopressin, but it is unclear whether this is a direct effect or is mediated through hypotension or nausea Oxytocin initiates uterine contraction and has milk-ejecting effects Its release is stimulated by distention of the cervix, labor,. pdf417 barcode generator javascript parse -usdl - npm
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