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In many chapters to follow, reference will be made to the ways in which the cerebrospinal uid (CSF) re ects the basic pathologic processes in a wide variety of in ammatory and infectious, metabolic, neoplastic, demyelinative, and degenerative diseases The CSF alterations in these varied circumstances raise so many interesting and important problems that we consider it worthwhile to discuss in one place the mechanisms involved in the formation, circulation, and absorption of the CSF, particularly as they pertain to increased intracranial pressure (ICP) Also to be considered in this chapter are hydrocephalus, pseudotumor cerebri, and syndromes produced by greatly reduced pressure in the CSF compartment In all of these conditions, the primary abnormalities are those of the CSF and its circulation Examination of the CSF as a diagnostic aid in neurology was discussed in Chap 2; the primary infective and noninfective in ammatory reactions of the pia-arachnoid (leptomeninges) and ependyma of the ventricles are considered in Chap 32 A few historical points call to mind that our knowledge of the physiology, chemistry, and cytology of the CSF is relatively recent Although the lumbar puncture was introduced by Quincke in 1891, it was not until 1912 that Mestrezat made the rst correlations between disease processes and the cellular and chemical changes in the CSF In 1937, Merritt and Fremont-Smith published their classic monograph on the CSF changes in all types of disease Most of our knowledge of CSF cytology has accumulated since the late 1950s, when membrane ltration techniques (particularly the cellulose ester or Millipore lter) were introduced The studies of Dandy (1919) and of Weed (1935) provided the basis of our knowledge of CSF formation, circulation, and absorption There followed the important studies of Pappenheimer and of Ames and their colleagues, and the monographs of Fishman and of Davson and coworkers, which are important recent contributions The cytology of the CSF is informatively summarized in the monographs of Dufresne and Den Hartog-Jager (see Chap 2 for references).

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addition, since the brain and spinal cord have no lymphatic channels, the CSF, through its sink action (see below), serves to remove the waste products of cerebral metabolism, the main ones being CO2, lactate, and hydrogen ions The composition of the CSF is maintained within narrow limits, despite major alterations in the blood; thus the CSF, along with the intercellular uid of the brain, helps to preserve a stable chemical environment for neurons and their myelinated bers There is no reason to believe that the CSF is actively involved in the metabolism of the cells of the brain and spinal cord In the adult, the average intracranial volume is 1700 mL; the volume of the brain is from 1200 to 1400 mL, CSF volume ranges from 70 to 160 mL (mean, 104), and that of blood is about 150 mL In addition, the spinal subarachnoid space contains 10 to 20 mL of CSF Thus, at most, the CSF occupies somewhat less than 10 percent of the intracranial and intraspinal spaces The proportion of CSF in the ventricles and cisternae and in the subarachnoid spaces between the cerebral hemispheres and the sulci varies with age These variations have been plotted in computed tomography (CT) scans by Meese and coworkers; the distance between the caudate nuclei at the anterior horns gradually widens by approximately 10 to 15 cm, and the width of the third ventricle increases from 3 to 6 mm by age 60 Formation The introduction of the ventriculocisternal perfusion technique by Pappenheimer and colleagues made possible accurate measurement of the rates of formation and absorption of the CSF It is now established that the average rate of CSF formation is 21 to 22 mL/h (035 mL/min), or approximately 500 mL/day The CSF as a whole is therefore renewed four or ve times daily The choroid plexuses, located in the oor of the lateral, third, and fourth ventricles, are the main sites of CSF formation (some CSF is formed even after the choroid plexuses are removed) The thin-walled vessels of the plexuses allow passive diffusion of substances from the blood plasma into the extracellular space surrounding choroid cellsThe choroidal epithelial cells, like other secretory epithelia, contain organelles, indicating their capacity for an energy-dependent secretory function, ie, active transport The blood vessels in the subependymal regions and the pia also contribute to the CSF, and some substances enter the CSF as readily from the meninges as from the choroid plexuses Thus, electrolytes equilibrate with the CSF at all points in the ventricular and subarachnoid spaces, and the same is true of glucose The transport of sodium, the main cation of the CSF, is accomplished by the action of a sodium-potassium-ion exchange pump at the apical surface of the choroid plexus cells, the energy for which is supplied by adenosine triphosphate; drugs that inhibit the ATP system reduce CSF 529.

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The primary function of the CSF appears to be a mechanical one; it serves as a kind of water jacket for the spinal cord and brain, protecting them from potentially injurious blows to the spinal column and skull and acute changes in venous pressure Also, it provides the brain with buoyancy As pointed out by Fishman, the 1500-g brain, which has a water content of approximately 80 percent, weighs only 50 g when suspended in CSF, so the brain virtually oats in its CSF jacket Many of the physiologic and chemical mechanisms described below are committed to maintaining the relatively constant volume-pressure relationships of the CSF In

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